温州大学化学与材料工程学院

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陈久喜

发布时间:2014-10-29 来源: 编辑: 点击[点击关闭]

个人简介
   陈久喜,男,汉族,1982年2月生,浙江乐清人,中共党员,医学博士,硕士生导师,副院长。2007年8月进入温州大学化学与材料工程学院工作。浙江省“151人才工程”第二层次、温州市青年拔尖人才、温州市“551人才工程”第一层次、温州市青年科技奖等。主持国家自然科学基金、浙江省自然科学基金和浙江省公益技术应用研究计划项目等,以研究骨干参与科技部“十一五”国家科技支撑计划、浙江省科技厅重大专项等项目;至今已在Org. Lett.; Chem. Commun.; J. Org. Chem.; Green Chem.; Adv. Synth. Catal. 等国际权威刊物上发表SCI论文100余篇,相关研究成果多次被SynfactOrganic Chemistry Protal评述。应邀为Org. Lett.; Chem. Commun.; Green Chem.; J. Org. Chem.等国际期刊审稿。申请国家发明专利40余项,其中授权专利20余项。获浙江省科学技术奖2项(排名第一和排名第三)
       研究方向:(1)药物分子设计、合成及评价;(2)有机合成新反应和新方法研究。
代表论文

[80]  Linjun Qi, Kun Hu, Shuling Yu, Jianghe Zhu, Tianxing Cheng, Xiaodong Wang, Jiuxi Chen*, Huayue Wu, Tandem addition/cyclization for access to isoquinolines and isoquinolones via catalytic carbopalladation of nitriles, Org. Lett. 2017, 19, 218-221. (SCI一区, IF=6.732)
[79] Kun Hu, Linqun Qi, Shuling Yu, Tianxing Cheng, Xiaodong Wang, Zhaojun Li, Yuanzhi Xia, Jiuxi Chen*, Huayue Wu, 
Efficient synthesis of isoquinolines in water by Pd-catalyzed tandem reaction of functionalized alkylnitriles with arylboronic acids, Green Chem. 2017, 19, 1740-1750. (SCI一区, IF=8.506)
[78] Shuling Yu, Linjun Qi, Kun Hu, Julin Gong, Tianxing Cheng, Qingzong Wang, Jiuxi Chen*, Huayue Wu*, The development of a palladium-catalyzed tandem addition/cyclization for construction of indole skeletons, J. Org. Chem. 2017, 82, 3631-3638. (SCI二区, IF=4.785)
[77] Shuling Yu, Kun Hu, Julin Gong, Linjun Qi, Jianghe Zhu, Yetong Zhang, Tianxing Cheng* and Jiuxi Chen*, Palladium-catalyzed tandem addition/cyclization in aqueous medium: synthesis of 2-arylindoles, Org. Biomol. Chem. 2017, 15, 4300-4307. (SCI 二区, IF=3.559) 封面论文
[76] Rui Qiao, Leping Ye, Kun Hu, Shuling Yu, Weiguang Yang, Miaochang Liu, Jiuxi Chen*, Jinchang Ding and Huayue Wu*, Copper-catalyzed C-O bond cleavage and cyclization: synthesis of indazolo[3,2-b]quinazolinones, Org. Biomol. Chem. 2017, 15, 2168-2173.【Highlighted by Synfacts 2017, 13(05), 475】 (SCI二区, IF=3.559) 封面论文
[75] Ya Zhang, Rui Qiao, Dan He, Zihui Zhao, Shanshan Yang, Huixi Zou, Xu Zhang, Mingjiang Wu, Jiuxi Chen*, Peichao Chen*, Indazolo[3,2-b]quinazolinones attack hepatocellular carcinoma hep3B cells by inducing mitochondrial-dependent apoptosis and inhibition of Nrf2/ARE signaling pathway, Curr. Mol. Med. 2016, 16, 820-828. (SCI二区)
[74] Weiguang Yang, Rui Qiao, Jiuxi Chen*, Xiaobo Huang, Miaochang Liu, Wenxia Gao, Jinchang Ding, Huayue Wu*, Palladium-catalyzed cascade reaction of 2-amino-N-arylbenzohydrazides with triethyl orthobenzoates to construct indazolo[3,2-b]quinazolinones, J. Org. Chem. 2015, 80, 482-489. (SCI二区, IF=4.785)
[73] Weiguang Yang, Jiuxi Chen*, Xiaobo Huang, Jinchang Ding, Miaochang Liu, Huayue Wu*, Pd-catalyzed intramolecular aerobic oxidative C?H amination of 2-aryl-3-(arylamino)quinazolinones: synthesis of fluorescent indazolo[3,2-b]quinazolinones, Org. Lett. 2014, 16, 5418-5421.【Highlighted by Synfacts 2014, 10(12), 1264】 (SCI一区, IF=6.732)
[72] Yan Shen, Jiuxi Chen*, Miaochang Liu, Jinchang Ding, Wenxia Gao, Xiaobo Huang, Huayue Wu*, Copper-catalyzed direct C-H arylation of pyridine N-oxides with arylboronic esters: one-pot synthesis of 2-arylpyridines, Chem. Commun. 2014, 50, 4292-4295. (SCI一区, IF=6.567) 封面论文
[71] Shaoxi Yan, Leping Ye, Miaochang Liu, Jiuxi Chen*, Jinchang Ding, Wenxia Gao, Xiaobo Huang, Huayue Wu*, Unexpected TFA-catalyzed tandem reaction of benzo[d]oxazoles with 2-oxo-2-arylacetic acids: synthesis of 3-aryl-2H-benzo[b][1,4]oxazin-2-ones and cephalandole A, RSC Adv. 2014, 4, 16705-16709. (SCI二区)
[70] Jiuxi Chen, Leping Ye, Weike Su*, Palladium-catalyzed direct addition of arylboronic acids to 2-aminobenzonitrile derivatives: synthesis, biological evaluation and in silico analysis of 2-aminobenzophenones, 7-benzoyl-2-oxoindolines, and 7-benzoylindoles, Org. Biomol. Chem. 2014, 12, 8204–8211. (SCI二区)
[69] Jiuxi Chen, Jianjun Li, Weike Su*, Palladium-catalyzed tandem reaction of 2-hydroxyarylacetonitriles with sodium sul?nates: one-pot synthesis of 2-arylbenzofurans, Org. Biomol. Chem. 2014, 12, 4078–4083. (SCI二区)
[68] Zhongyan Chen, Jiuxi Chen*, Miaochang Liu, Jinchang Ding, Wenxia Gao, Xiaobo Huang, Huayue Wu*, Unexpected copper-catalyzed cascade synthesis of quinazoline derivatives, J. Org. Chem. 2013, 78, 11342-11348.【Featured online at the Organic Chemistry Portal】(SCI二区)
[67] Fujun Duan, Miaochang Liu, Jiuxi Chen*, Jinchang Ding, Yuefei Hu, Huayue Wu*, Copper-catalyzed sequential arylation and intramolecular annulation of 2-(2-bromophenyl)-2,3-dihydroquinazolin-4(1H)-ones with amidines, RSC Adv. 2013, 3, 24001-24004. (SCI二区)
[66] Weiguang Yang, Leping Ye, Dayun Huang, Miaochang Liu, Jinchang Ding,* Jiuxi Chen*, Huayue Wu, Copper-catalyzed intramolecular C-N bond formation reaction of 3-amino-2-(2-bromophenyl)dihydroquinazolinones: synthesis of indazolo[3,2-b]quinazolinones, Tetrahedron 2013, 69, 9852-9856. (SCI三区)
[65] Xingyong Wang, Miaochang Liu, Long Xu, Qingzong Wang, Jiuxi Chen*, Jinchang Ding, Huayue Wu*, Palladium-catalyzed addition of potassium aryltri?uoroborates to aliphatic nitriles: synthesis of alkyl aryl ketones, diketone compounds, and 2-arylbenzo[b]furans, J. Org. Chem. 2013, 78, 5273-5281.【Featured online at the Organic Chemistry Portal】(SCI二区)
[64] Miaochang Liu, Shaomiao Lin, Jinchang Ding, Wenxia Gao, Huayue Wu, Jiuxi Chen*, Decarboxylation of isatoic anhydrides with disul?des: an ef?cient and general synthesis of S-aryl 2-aminobenzothioate derivatives, Tetrahedron 2013, 69, 2283-2288. (SCI三区)
[63] Xingyong Wang, Xiaodong Wang, Miaochang Liu,* Jinchang Ding, Jiuxi Chen,* Huayue Wu, Palladium-catalyzed reaction of arylboronic acids with aliphatic nitriles: syn-thesis of alkyl aryl ketones and 2-aryl benzofurans, Synthesis 2013, 45, 2241-2244.【Highlighted by Synfacts 2013, 9(10), 1058】(SCI三区)
[62] Dayun Huang, Jiuxi Chen*, Weixing Dan, Jinchang Ding, Miaochang Liu, Huayue Wu*, A metal-free sulfenylation and bromosulfenylation of indoles: controllable synthesis of 3-arylthioindoles and 2-bromo-3-arylthioindoles, Adv. Synth. Catal. 2012, 354, 2123-2128. (SCI一区)
[61] Jiuxi Chen*, Xingyong Wang, Xingwang Zheng, Jinchang Ding, Miaochang Liu, Huayue Wu*, Ligand-free copper-catalyzed O-arylation of nitroarenes with phenols, Tetrahedron 2012, 68, 8905-8907. (SCI三区)
[60] Gaigai Liang, Jing Chen, Jiali Chen, Wanmei Li, Jiuxi Chen,* Huayue Wu, Sc(OTf)3-catalyzed synthesis of thiosulfonates in ionic liquid-water, Tetrahedron Lett. 2012, 53, 6768-6770. (SCI三区)
[59] Jiuxi Chen*, Yong Peng, Miaochang Liu, Jinchang Ding, Weike Su, Huayue Wu*, Palladium-catalyzed aerobic oxidative coupling of acyl chlorides with arylboronic acids, Adv. Synth. Catal. 2012, 354, 2117-2122. (SCI一区)
[58] Jilei Zhang, Jiuxi Chen*, Miaochang Liu, Xingwang Zheng, Jinchang Ding, Huayue Wu*, Ligand-free copper-catalyzed coupling of nitroarenes with arylboronic acids, Green Chem. 2012, 14, 912-916. (SCI一区)
[57] Jiuxi Chen, Rongalite, Synlett 2012, 157-158 (Spotlight 378) (SCI三区)
[56] Wei Lu, Jiuxi Chen*, Miaochang Liu, Jinchang Ding, Wenxia Gao, Huayue Wu*, Palladium-catalyzed decarboxylative coupling of isatoic anhydrides with arylboronic acids, Org. Lett. 2011, 13, 6114-6117. (SCI一区)
[55] Jilei Zhang, Jiuxi Chen*, Jinchang Ding, Miaochang Liu, Huayue Wu, Copper-catalyzed arylation of indolin-2,3-ones with arylboronic acids, Tetrahedron 2011, 67, 9347-9351. (SCI三区)
[54] Xingwang Zheng, Jinchang Ding, Jiuxi Chen*, Wenxia Gao, Miaochang Liu, Huayue Wu*, The coupling of arylboronic acids with nitroarenes catalyzed by rhodium. Org. Lett. 2011, 13, 1726-1729. (SCI一区)
[53] Hanmei Zheng, Jinchang Ding, Jiuxi Chen*, Miaochang Liu, Wenxia Gao, Huayue Wu*, Copper-catalyzed arylation of arylboronic acids with aldehydes, Synlett 2011, 1626-1630. (SCI三区)
[52] Yong Peng, Jiuxi Chen*, Jinchang Ding, Miaochang Liu, Wenxiao Gao, Huayue Wu*, Ligand-free copper-catalyzed arylation of olefins by the Mizoroki–Heck reaction, Synthesis 2011, 213. (SCI三区)
[51] Xiaoling Xu, Jiuxi Chen*, Wenxia Gao, Huayue Wu,* Jinchang Ding, Weike Su, Palladium-catalyzed hydroarylation of alkynes with arylboronic acids, Tetrahedron 2010, 66, 2433-2438. (SCI三区)
[50] Wenxue Guo, Guangshu Lv, Jiuxi Chen*, Wenxia Gao, Jinchang Ding, Huayue Wu* Rongalite? and base-promoted cleavage of disulfides and subsequent Michael addition to α,β-unsaturated ketones/esters: an odorless synthesis of β-sulfido carbonyl compounds, Tetrahedron 2010, 66, 2297-2300. (SCI三区)
[49] Weixing Dan, Hongjuan Deng, Jiuxi Chen*, Miaochang Liu, Jinchang Ding, Huayue Wu*, A new odorless one-pot synthesis of thioesters and selenoesters promoted by Rongalite, Tetrahedron 2010, 66, 7384-7388. (SCI三区)
[48] Wenxue Guo, Jiuxi Chen*, Dengze Wu, Jinchang Ding, Fan Chen, Huayue Wu*, Rongalite promoted highly regioselective synthesis of β-hydroxy sul?des by ring opening of epoxides with disulfides, Tetrahedron 2009, 65, 5240-5243. (SCI三区)
[47] Jiuxi Chen, Dengze Wu, Fei He, Miaochang Liu, Huayue Wu, Jinchang Ding and Weike Su*, Gallium(III) triflate-catalyzed one-pot selective synthesis of 2,3-dihydroquinazolin -4(1H)-ones and quinazolin-4(3H)-ones, Tetrahedron Lett. 2008, 49, 3814-3818.【Highlighted by Synfacts 2008, 807】(SCI三区)
[46] Jiuxi Chen, Weike Su*, Huayue Wu*, Miaochang Liu, Can Jin, Eco-friendly synthesis of 2,3-dihydroquinazolin-4(1H)-ones in ionic liquids or ionic liquid–water without additional catalyst. Green Chem. 2007, 9, 972-975. (SCI一区)
[45] Weike Su,* Jiuxi Chen, Huayue Wu, Can Jin, A general and efficient method for the selective synthesis of β-hydroxy sulfides and β-hydroxy sulfoxides catalyzed by gallium(III) triflate. J. Org. Chem. 2007, 72, 4524-4527. (SCI二区)
[44] Jiuxi Chen, Huayue Wu,Zhiguo Zheng,Can Jin,Xingxian Zhang, Weike Su*, An approach to the Paal–Knorr pyrroles synthesis catalyzed by Sc(OTf)3 under solvent-free conditions, Tetrahedron Lett. 2006, 47, 5383-5387. (SCI三区)
[43] Jiuxi Chen, Huayue Wu, Can Jin, Xingxian Zhang, Yuanyuan Xie, Weike Su*, Highly regioselective ring-opening of epoxides with thiophenols in ionic liquids without the use of any catalyst, Green Chem. 2006, 8, 330-332. (SCI一区)
[42] Hongjuan Deng, Yjing Fang, Gaowei Chen, Miaochang Liu, Huayue Wu, Jiuxi Chen*, Copper-catalyzed Clauson–Kass pyrroles synthesis in aqueous media, Appl. Organometal. Chem. 2012, 26, 164-167. (SCI, IF: 2.011)
[41] Huile Jin, Tianxing Cheng, Jiuxi Chen*, Cerium-catalyzed tandemsynthesis of 2-substituted benzothiazoles in PEG, Appl. Organometal. Chem. 2011, 25, 238–240. (SCI, IF: 2.011)
[40] Qiang Zhang, Chunmei Xu, Jiuxi Chen*, Xiaoling Xu, Jinchang Ding, Huayue Wu*, Palladium-catalyzed arylation of arylglyoxals with arylboronic acids, Appl. Organometal. Chem. 2009, 23, 524–526. (SCI, IF: 2.011)
[39] Qiang Zhang, Jiuxi Chen*, WenxiaGao, Jinchang Ding and Huayue Wu*, Copper-catalyzed one-pot synthesis of propargylamines via C–H activation in PEG. Appl. Organometal. Chem. 2010, 24, 809-812.
[38] Xingyong Wang, Qingzong Wang, Jiuxi Chen, Miaochang Liu*, Jinchang Ding, Huayue Wu, Palladium-catalysed addition of potassium phenyltrifluoroborate to dinitriles: synthesis of diketone compounds, J. Chem. Res. 2013, 37, 470-472.
[37] Fujun Duan, Jinchang Ding, Hongjuan Deng, Dingben Chen, Jiuxi Chen, Miaochang Liu*, Huayue Wu*, An approach to the Paal–Knorr pyrroles synthesis in the presence of β-cyclodextrin in aqueous media, Chin. Chem. Lett. 2013, 24, 793–796.
[36] Tieqiang Huang, Jinchang Ding, Miaochang Liu, Wenxia Gao, Huayue Wu, Jiuxi Chen*, Catalyst-free protocol for the synthesis of quinoxalines and pyrazines in PEG, J. Heterocyclic Chem. 2013, 50, 293-297.
[35] Shaojin Gu, Bo Liu, Jiuxi Chen, Huayue Wu*, Wanzhi Chen,* Synthesis, structures, and properties of ruthenium(II) complexes of N-(1,10-phenanthrolin-2-yl)imidazolylidenes, Dalton Trans. 2012, 41, 962-970.
[34] Hui Xu, Wanzhi Chen,* Jiuxi Chen, Huayue Wu*, Stereoselective synthesis of (Z)-1,2-dithio-1-alkenes via copper-catalyzed thiolation of (Z)-2-bromovinyl sulfides, Synthesis 2012, 380–388.
[33] Guangshu Lv, Fujun Duan, Jinchang Ding, Tianxing Cheng, Wenxia Gao, Jiuxi Chen*, Huayue Wu, Tandem base-free synthesis of β-hydroxy sulphides under ultrasound irradiation, J. Chem. Sci. 2012, 124, 1057–1062.
[32] Quansheng Ding, Jilei Zhang, Jiuxi Chen*, Miaochang Liu, Jinchang Ding, Huayue Wu*, Tandem synthesis of 2,3-dihydroquinazolin-4(1H)-ones on grinding under solvent-free conditions, J. Heterocyclic Chem. 2012, 49, 375-380.
[31] Gaigai Liang, Miaochang Liu, Jiuxi Chen*, Jinchang Ding, Wenxia Gao and Huayue Wu*, NBS-promoted sulfenylation of sulfinates with disulfides leading to unsymmetrical or symmetrical thiosulfonates, Chin. J. Chem. 2012, 30, 1611-1616.
[30] Chuanli Shi, Jinchang Ding, Jun Jiang, Jiuxi Chen, Huayue Wu, Miaochang Liu*, Ligand-free palladium-catalysed oxidative Heck reaction of 4-vinylpyridine with arylboronic acids: selective synthesis of (E)-4-styrylpyridines, J. Chem. Res. 2012, 322-325.
[29] Jun Li, Danna Jiang, Jiuxi Chen*, Miaochang Liu, Jinchang Ding, Huayue Wu*, Eco-friendly synthesis of quinoxaline derivatives by grinding under solvent-free conditions. J. Heterocyclic Chem. 2011, 48, 403-406.
[28] Tieqiang Huang, Jun Li, Jiuxi Chen*, Wenxia Gao, Jinchang Ding, Huayue Wu*. Silica sulfuric acid (SSA)/peg as a recyclable system for the synthesis of quinoxalines and pyrazines, Synth. Commun. 2011, 41, 3334–3343.
[27] Mingtiao Cai, Guangshu Lv, Jiuxi Chen*, Wenxia Gao, Jinchang Ding, Huayue Wu*, CAN/I2-catalyzed Chemoselective Synthesis of Thiosulfonates by Oxidation of Disulfides or Thiols, Chem. Lett. 2010, 39, 368-369.
[26] Shaomiao Lin, Jilei Zhang, Jiuxi Chen*, Wenxia Gao, Jinchang Ding, Weike Su, Huayue Wu*, An Approach to Synthesis of Thioesters and Selenoesters Promoted by Rongalite?, J. Braz. Chem. Soc. 2010, 21, 1616-1620.
[25] Xiaoliang Yang, Chunmei Xu, Shaomiao Lin, Jiuxi Chen,*, Jinchang Ding, Huayue Wu*, Weike Su, Eco-Friendly Synthesis of 2-Substituted Benzothiazoles Catalyzed by Cetyltrimethyl Ammonium Bromide (CTAB) in Water, J. Braz. Chem. Soc. 2010, 21, 37-42.
[24] Shuanghua Cheng, Jiuxi Chen,* Wenxia Gao, Huile Jin, Jinchang Ding, Huayue Wu*, Oxidative esterification of aldehydes with alcohols and phenols in air, J. Chem. Res. 2010, 130-132.
[23] Yali Xu, Jiuxi Chen, Wenxia Gao, Huile Jin, Jinchang Ding, Huayue Wu*, Solvent-free synthesis of 3,5-di(hetero)aryl-1,2,4-thiadiazoles by grinding of thioamides under oxidative conditions. J. Chem. Res. 2010, 151-153.
[22] Jiuxi Chen, Changfu Zhang, Wenxia Gao, Huile Jin, Jinchang Ding, Huayue Wu*, B2O3/Al2O3 as a new, highly efficient and reusable heterogeneous catalyst for the selective synthesis of β-enamino ketones and esters under solvent-free conditions, J. Braz. Chem. Soc. 2010, 21, 1552-1556.
[21] Hanmei Zheng, Qiang Zhang, Jiuxi Chen, Miaochang Liu, Shuanghua Cheng, Jinchang Ding,* Huayue Wu*, Weike Su, Copper(II) acetate-catalyzed addition of arylboronic acids to aromatic aldehydes, J. Org. Chem.2009, 74, 943-945.
[20] Huilong Xiao, Jiuxi Chen, Miaochang Liu, Dongjian Zhu, Jinchang Ding*, Huayue Wu*, Trichloroisocyanuric acid (TCCA) as a mild and efficient catalyst for the synthesis of 2-arylbenzothiazoles, Chem. Lett. 2009, 38, 170-171.
[19] Bing Zuo, Jiuxi Chen, Miaochang Liu, Huayue Wu*, Weike Su* ,Yb(OTf)3-catalyzed synthesis of pyrroles under solvent-free conditions, Chin. Chem. Lett.2009, 20, 423–426.
[18] Bing Zuo, Jiuxi Chen, Miaochang Liu, Jinchang Ding; Huayue Wu*, Weike Su*, Scandium Triflate-catalysed synthesis of N-substituted pyrroles from amine and 2,5-dimethoxytetrahydrofuran, J. Chem. Res. 2009, 14-16.
[17] Dongjian Zhu, Jiuxi Chen, Miaochang Liu, Jinchang Ding, Huayue Wu*, Catalyst and Solvent-free Synthesis of Imidazo[1,2-a]pyridines, J. Braz. Chem. Soc. 2009, 20, 482-487.
[16] Wei Xiong, Jiuxi Chen, Miaochang Liu, Jinchang Ding, Huayue Wu*, Weike Su*, A general and efficient synthesis of pyrazoles catalyzed by Sc(OTf)3 under Solvent-Free Conditions, J. Braz. Chem. Soc. 2009, 20, 367-374.
[15] Tieqiang Huang, Qaing Zhang, Jiuxi Chen*, Wenxia Gao, Jinchang Ding, Huayue Wu*, Synthesis of quinoxalines catalysed by cetyltrimethyl ammonium bromide (CTAB) in aqueous media, J. Chem. Res. 2009, 761-765.
[14] Dongjian Zhu, Jiuxi Chen, Dengze Wu, Miaochang Liu, Jinchang Ding, Huayue Wu*, An Efficient, Catalyst- and Solvent-free Synthesis of Imidazo-[1,2-a]pyridines and 2,4-Disubstituted Thiazoles on Grinding, J. Chem. Res. 2009, 84-86.
[13] Dongjian Zhu, Jiuxi Chen, Huilong Xiao, Miaochang Liu, Jinchang Ding, Huayue Wu*, Efficient and expeditious synthesis of di- and trisubstituted thiazoles in PEG under catalyst-Free Conditions, Synth. Commun. 2009, 39, 2895–2906.
[12] Jiuxi Chen, Xiaoliang Yang, Miaochang Liu, Huayue Wu*, Jinchang Ding, Weike Su, Approach to synthesis of β-enamino ketones and pyrroles catalyzed by gallium(III) triflate under solvent-free conditions, Synth. Commun. 2009, 39, 4180–4198.
[11] Wenxue Guo, Huile Jin, Jiuxi Chen*, Fan Chen, Jinchang Ding, Huayue Wu*, An Efficient Catalyst-Free Protocol for the Synthesis of Quinoxaline Derivatives under Ultrasound Irradiation, J. Braz. Chem. Soc. 2009, 20, 1674-1679.
[10] Xiaoliang Yang, Yali Xu, Jiuxi Chen*, Jinchang Ding, Huayue Wu*, Weike Su, Sodium dithionite-promoted synthesis of 2-arylbenzothiazoles by reaction of 2,2-disulfanediyldianiline with aldehydes in water, J. Chem. Res. 2009, 682–685.
[9] Huilong Xiao, Jiuxi Chen, Miaochang Liu, Huayue Wu*, Jinchang Ding, An Approach to Disulfide Synthesis Promoted by Sulfonyl Chloride in Sodium Bicarbonate Aqueous Media, Phosphorus, Sulfur, and Silicon, 2009,184,2553–2559.
[8] Mingtiao Cai, Jiuxi Chen, Xiaobo Huang, Miaochang Liu, Jinchang Ding*, Huayue Wu*, Synthesis of fluorinated β-carbolines by one-pot reaction, J. Chem. Res. 2008, 296-298.
[7] Changming Qin, Huayue Wu*, Jiuxi Chen, Miaochang Liu, Jiang Cheng,* Weike Su, Jinchang Ding, Palladium-catalyzed aromatic esterification of aldehydes with organoboronic acids and molecular oxygen, Org. Lett. 2008, 10, 1537-1540.
[6] Qiang Zhang, Jiuxi Chen, Miaochang Liu, Huayue Wu*, Jiang Cheng,* Changming Qin, Weike Su, Jinchang Ding, Palladium-catalyzed addition of arylboronic acids to N-tosylarylimines, Synlett 2008, 6, 935-939.
[5]. Changming Qin, Jiuxi Chen, Huayue Wu*, Jiang Cheng, Qiang Zhang, Bing Zuo, Weike Su, Jinchang Ding, One-pot synthesis of diaryl ketones from aldehydes via palladium-catalyzed reaction with aryl boronic acids, Tetrahedron Lett. 2008, 49, 1884–1888.
[4] Changfu Zhang, Jiuxi Chen, Xiaochun Yu, Xian Chen, Huayue Wu*, Jianping Yu, B2O3/Al2O3 as an efficient and recyclable catalyst for the synthesis of β-amino alcohols under solvent-free conditions, Synth. Commun. 2008, 38, 1875–1887.
[3] Fei He, Huayue Wu, Jiuxi Chen, Weike Su, Unexpectedly high activity of Zn(OTf)2?6H2O in catalytic Friedel–Crafts acylation reaction, Synth. Commun. 2008, 38, 255–264.
[2] Jiuxi Chen, Miaochang Liu, Xiaoliang Yang, Jinchang Ding, Huayue Wu*, Indium(III)-catalyzed synthesis of N-substituted pyrroles under solvent-free conditions, J. Braz. Chem. Soc. 2008, 19, 877-883.
[1] Jiuxi Chen, Huayue Wu*, Weike Su,A facile synthesis of 2,3-dihydro-2-aryl-4(1H)-quinazolinones catalyzed by scandium(III) triflate, Chin. Chem. Lett. 2007, 18, 536–538.

主要项目

[1] 主持国家自然科学基金(批准号:21572162)"过渡金属催化官能团化腈与有机硼试剂的串联反应研究-氮杂环构建新策略"(2016.01-2019.12)  
[2] 主持国家自然科学基金(批准号:21102105)"过渡金属催化靛红酸酐与有机硼酸的脱羧偶联反应研究"  (2012.01-2014.12) 
[3] 主持浙江省自然科学基金(编号:LY14B020009)“基于串联反应构建含硒化合物的方法学研究”(2014.01-2016.12) 
[4] 主持浙江省公益技术应用研究计划项目(编号:2016C31022)“抗炎药普罗纳克关键中间体的合成新工艺研究”(2016.01-2017.12) 
[5]主持浙江省自然科学基金(编号:Y4080107)“功能化手性离子液体的合成及在环氧不对称开环反应中的应用”(2009.01-2010.12) 
[6] 主持温州市科技计划项目(编号:G20100065)“胃肠解痉药马来酸曲美布汀关键中间体绿色合成新工艺研发”(2010.01-2011.12) 

授权专利

[1]  陈久喜,高文霞,刘妙昌,卢娓,吴华悦“一种邻氨基芳甲酸芳基酯衍生物的合成方法”授权发明专利,专利号:ZL201110282338.7
[2]  陈久喜,高文霞,刘妙昌,蒋俊,吴华悦“一种S-(4-甲苯基)苯磺酸酯的化学合成方法”授权发明专利,专利号:ZL201110411391.2
[3] 陈久喜,吴华悦,刘妙昌,丁金昌“一种3-芳巯基吲哚类化合物的合成方法”授权发明专利,专利号:ZL201110411943.X
[4]陈久喜,吴华悦,刘妙昌,丁金昌 “2-溴-3-芳巯基吲哚类化合物及其制备方法和应用”授权发明专利,专利号:ZL201110451701.3
[5] 陈久喜,刘妙昌,高文霞,黄小波,吴华悦“一种S-苯基-4-甲苯磺酸酯的化学合成方法”授权发明专利,专利号:ZL201110411469.0
[6] 陈久喜,刘妙昌,高文霞,张吉磊,吴华悦“一种3-羟基-3-芳基吲哚-2-酮衍生物的合成方法”授权发明专利,专利号:ZL201110282142.8
[7]陈久喜,吴华悦,刘妙昌,丁金昌“一种芳甲酸芳基酯衍生物的合成方法”授权发明专利,专利号:ZL201110451903.8
[8]陈久喜,彭勇,高文霞,吴华悦“一种3,4,5-三甲氧基苯甲酰氯的化学合成方法”授权发明专利,专利号:ZL201110411753.8
[9] 陈久喜,吴华悦,王兴永,刘妙昌,高文霞,黄小波“一种二芳基苯胺化合物的合成方法”授权发明专利,专利号: ZL201310312799.3
[10] 陈久喜,刘妙昌,王兴永,黄小波,高文霞,吴华悦“一种2-芳基苯并呋喃类化合物的合成方法”授权发明专利,专利号:ZL201310171930.9

获奖及荣誉

[1] 2016年获“温州市青年拔尖人才”称号(每两年入选20人) 
[2] 2014年入选浙江省“151人才工程”第二层次
[3] 2014年入选温州市“551人才工程”第一层次
[4] 2011年入选浙江省“151人才工程”第三层次
[5] 2011年获第二届温州市青年科技奖(每两年入选10人) 
[6] 2010年入选温州市“551人才工程”第二层次
[7] 2012年获“十一五”浙江省自然科学基金优秀项目(排名第一)
[8] 2010年获浙江省科学技术奖三等奖 "含氮杂环及β-羟基类化合物的绿色合成研究"(排名第一)
[9] 2009年获浙江省科学技术奖三等奖 "绿色化学技术及金属试剂在有机合成中的应用研究"(排名第三) 

部分优秀硕士毕业生 [1] 10级硕士生:黄达云,2013.09-2016.06,清华大学,博士研究生,现任职于丽水学院。
[2] 10级硕士生:王兴永,2014年考取清华大学博士研究生。
[3] 11级硕士生:陈忠研,2014年考取南京大学博士研究生。
[4] 12级硕士生:杨渭光,2015年考取清华大学博士研究生。
[5] 14级硕士生:戚林军,2017年考取厦门大学博士研究生。

联系方式 本课题组常年招收有机化学及药物化学等相关专业硕士研究生,有意者请与我联系

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