高文霞-温州大学化学与材料工程学院

温州大学化学与材料工程学院

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高文霞

发布时间:2014-11-14    来源:    作者:    点击次    [点击关闭]

个人简介
                                       

高文霞,女,副教授,毕业于合肥工业大学,主要从事生物医用材料研究。

电子邮件:wenxiag@wzu.edu.cn

电话:13957778035

   
主要研究论文

1.         Xu  Long, Yang Yidi, Zhao Mingying, Zhang Hai, Li Sai, Wenxia Gao*, Bin He; Yuji Pu *. A reactive oxygen species–responsive prodrug micelle with efficient cellular uptake and excellent bioavailability, J. Mater. Chem. B, 2018, 6, 1076-1084.

2.         Long Xu, Mingying Zhao, Yidi Yang, Yan Liang, Changzhen Sun, Wenxia Gao*, Sai Li, Bin He, Yuji Pu*. A reactive oxygen species (ROS)-responsive low molecular weight gel co-loaded with doxorubicin and Zn(II) phthalocyanine tetrasulfonic acid for combined chemo-photodynamic therapy, J. Mater. Chem. B, 2017, 5, 9157-9164.

3.         Na Hao ; Changzhen Sun; Zhenfei Wu; Long Xu; ; Jun Cao; Wenxia Gao*, Li Li*; Bin He. Fabrication of Polymeric Micelles with Aggregation-Induced Emission and Forster Resonance Energy Transfer for Anticancer Drug Delivery, Bioconjugate Chemistry, 2017, 28, 1944-1954.

4.         Taotao Xu ; Junhua Li; Jun Cao; Wenxia Gao*; Li Li* ; Bin He. The effect of α-cyclodextrin on poly(pseudo)rotaxane nanoparticles self-assembled by protoporphyrin modified poly(ethylene glycol) for anticancer drug delivery, Carbohydrate Polymers, 2017, 174, 789-797.

5.         Ning Tao ; Guotao Li; Miaochang Liu; Wenxia Gao*; Huayue Wu* . Preparation of dual responsive low-molecular-weight hydrogel for long-lasting drug delivery, Tetrahedron, 2017, 73, 3173-3180.

6.         Yan Liang, Wenxia Gao*, Xinyu Peng, Xin Deng, Changzhen Sun, Huayue Wu, Bin He*. Near infrared light responsive hybrid nanoparticles for synergistic therapy. Biomaterials, 2016, 100, 76-90.

7.         Wenxia Gao, Yan Liang*, Xinyu Peng, Yalong Hu, Longgui Zhang, Huayue Wu, Bin He*. In situ injection of phenylboronic acid based low molecular weight gels for efficient chemotherapy. Biomaterials, 2016, 105, 1-11.

8.         Yalong Hu, Wenxia Gao*, Fang Wu, Huayue Wu, Bin He, Jing He*. Low molecular weight gels induced differentiations of mesenchymal stem cells. J. Mater. Chem. B, 2016, 4, 3504-3508.

9.         Long Xu, Yalong Hu, Miaochang Liu, Jiuxi Chen, Xiaobo Huang, Wenxia Gao*, Huayue Wu*. Gelation properties and glucose-sensitive behavior of phenylboronic acid based low-molecular-weight organogels. Tetrahedron, 2015, 71, 2079-2088.

10.     Kaiwen Yang, Sicheng Wan, Binbin Chen, Wenxia Gao*, Jiuxi Chen, Miaochang Liu, Huayue Wu*. Dual pH and temperature responsive hydrogels based β-cyclodextrin derivatives for atorvastatin delivery. Carbohy. Polym., 2015, 136, 300-306.

11.     Chaoyu Zhou, Wenxia Gao*, Kaiwen Yang, Long Xu, Jiuxi Chen, Miaochang Liu, Xiaobo Huang, Huayue Wu*. A novel glucose/pH responsive low-molecular-weight organogel of easy recycling. Langmuir, 2013, 29, 13568-13575.

12.     Chaoyu Zhou, Wenxia Gao*, Guangming Lu, Xiuming Wu, Xiaobo Huang, Jiuxi Chen, Huayue Wu*. Preparation, characterization and in vitro release of microparticles based on dextran-rosuvastatin conjugate. Carbohy. Polym., 2013, 96, 156-162.

13.     Xiepeng Lin, Wenxia Gao*, Chenen Li, Jiuxi Chen, Chen Yang, Huayue Wu*. Nano-sized flake carboxymethyl cassava starch as excipient for solid dispersions. Int. J. Pharmaceut., 2012, 423, 435-439.

14.     Wenxia Gao,Xiaoqing Lin, Xiepeng Lin, Jinchang Ding, Xiaobo Huang, Huayue Wu*. Preparation of nano-sized flake carboxymethyl cassava starch under ultrasonic irradiation. Carbohy. Polym., 2011, 84, 1413-1418.

15.     Xiepeng Lin, Wenxia Gao*, Xiaobo Huang, Panlong Zang, Jiuxi Chen, Huayue Wu*. Morphology-controlled hollow nanospheres of functionalized dextran by self-assembly in aqueous solution. Carbohy. Polym., 2010, 82, 460-465.

主要科研项目             

1.         国家自然科学基金面上项目,21672164,近红外光多点触发高灵敏刺激响应的功能分子设计、合成及载药系统研究,2017.01.01-2020.12.3165万元,在研,主持

2.         温州市科技局项目,Y20170162,高效抗非小细胞肺癌双硫仑-高分子胶束纳米药物研究,2017.07.01-2019.12.312万元,在研,主持

3.         浙江省自然科学基金,LY15B020001,基于有机小分子凝胶非共价方式门控的智能介孔骨架型药物载体的构建及性能研究,2015.01.01-2017.12.318万元,已结题,主持

4.         国家自然科学基金青年基金,21202122,葡萄糖快速响应型有机小分子凝胶的设计、合成及性能研究,2013.01.01-2015.12.3125万元,已结题,主持

5.         浙江省科技厅公益项目,2013C33188,有机硼酸小分子凝胶类胰岛素控释材料的设计合成与应用开发研究,2013.01.01-2014.12.3110万元,已结题,主持

6.         温州市科技局项目,G200900795-氨基-2--N-(2,4-二甲苯基)-苯磺酰胺清洁生产工艺开发,2009-201110万元,已结题,主持

授权专利

   

1.         高文霞, 吴华悦, 周超宇, 陈久喜, 刘妙昌, 黄小波, 蒋俊, 万思成。一种苯硼酸类有机凝胶化合物, ZL201210375089.0.

2.         高文霞, 徐龙, 吴华悦, 陈久喜, 刘妙昌, 黄小波, 蒋俊。 一类苯硼酸类有机凝胶化合物, ZL201310361889.1.

3.         高文霞, 吴华悦, 万思成, 陈久喜, 刘妙昌, 黄小波, 陈彬彬, 杨凯文。一种环境敏感型环糊精衍生物水凝胶的制备方法, ZL201410504485.8.

4.         吴华悦; 高文霞; 刘妙昌; 陈久喜; 韩丹丹; 狄安利; 池艳艳; 金杰, 一种杀扑磷纳米乳剂及其制备方法, ZL201210376780.0

5.         高文霞; 吴华悦; 陈久喜; 刘妙昌; 林勰鹏; 杨臣, 一种纳米级片状羧甲基淀粉钠在固体分散体中的应用, ZL 201110339510.8

6.         高文霞; 吴华悦; 李晨恩; 刘妙昌; 陈久喜, 一种氯氰菊酯水乳剂及其制备方法, ZL 201110331083.9

7.         吴华悦; 高文霞; 刘妙昌; 陈久喜; 周超宇; 卢广敏, 一种瑞舒伐他汀-右旋糖酐酯的制备方法, ZL 201110329343.9

8.         高文霞; 吴华悦; 陈久喜; 刘妙昌; 林勰鹏, 一种纳米级片状羧甲基淀粉钠的制备方法, ZL 201110009231.5 

  

主要获奖情况

2015,浙江省151人才第三层次

2014,温州市551人才第二层次

2012,温州市551人才第三层次   

2012,第十四届温州市自然科学优秀论文奖

2010,浙江省第六届青年教师教学技能奖