温州大学化学与材料工程学院

网站首页 考博网 温州大学 ENGLISH

科学研究

祝贺张兴国和张小红老师指导研究生在ORGANIC & BIOMOLECULAR CHEMISTRY上发表学术论文

发布时间:2018-03-20    来源:    作者:    点击次    [点击关闭]

标题:Palladium-catalyzed dimerization of N-aryl propargylamines for the synthesis of 3-vinylquinolines

AbstactA straightforward method for the synthesis of polyfunctionalized quinolines from readily available N-aryl propargylamines under aerobic conditions was developed. It provides convenient access to a variety of synthetically and pharmaceutically important quinolines in moderate to good yields. Control experiments suggest that the cascade reaction might proceed via the Pd-catalyzed electrophilic cyclization of N-aryl propargylamines followed by a hydroarylation process through trapping of the σ-quinolinylpalladium intermediate with a second molecule of the substrate.

 

原文链接: https://doi.org/10.1039/c8ob00133b