温州大学化学与材料工程学院

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祝贺陈久喜老师指导的研究生在ORGANIC LETTERS上发表学术论文

发布时间:2018-05-13    来源:    作者:    点击次    [点击关闭]

标题:Palladium-Catalyzed Three-Component Tandem Process: One-Pot Assembly of Quinazolines

AbstactThe first example of the palladium-catalyzed, threecomponent tandem reaction of 2-aminobenzonitriles, aldehydes, and arylboronic acids has been developed, providing a new approach for onepot assembly of diverse quinazolines in moderate to good yields. A noteworthy feature of this method is the tolerance of bromo and iodo groups, which affords versatility for further synthetic manipulations. Preliminary mechanistic experiments indicate that this tandem process involves two possible mechanistic pathways for the formation of quinazolines via catalytic carbopalladation of the cyano group.

 

原文链接:

http://dx.doi.org/10.1021/acs.orglett.8b01070