祝贺徐清和李欢老师指导的研究生在The Journal of Organic Chemistry上发表学术论文-温州大学化学与材料工程学院

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祝贺徐清和李欢老师指导的研究生在The Journal of Organic Chemistry上发表学术论文

发布时间:2018-06-06    来源:    作者:    点击次    [点击关闭]

标题:Specific N-Alkylation of Hydroxypyridines Achieved by a Catalyst- and Base-Free Reaction with Organohalides

 

AbstactA specific N-alkylation of 2-hydroxypyridines is achieved by reacting with organohalides under catalyst- and base-free conditions. The observed HX-facilitated conversion of pyridyl ether intermediates to 2-pyridone products may account for the success and specific N-alkylation of the reaction under the unexpectedly simple conditions. This new reaction may provide a useful alternative for the synthesis of 2-pyridones and analogous structures because of its >99% N-selectivity, relatively broad scopes of both substrates, and no mandatory use of catalysts and bases.

 

原文链接:

https://doi.org/10.1021/acs.joc.8b00787