温州大学化学与材料工程学院

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科学研究

祝贺陈久喜老师指导研究生在Advanced Synthesis & Catalysis上发表学术论文

发布时间:2018-06-22    来源:化学与材料工程学院    作者:    点击次    [点击关闭]

标题:Palladium-Catalyzed Tandem Reaction of Quinazolinone-Based Nitriles with Arylboronic Acids: Synthesis of 2-(4-Arylquinazolin-2-yl)anilines

AbstactA palladium-catalyzed tandem reaction of 2- (quinazolinone-3(4H)-yl)benzonitriles with arylboronic acids has been developed, allowing access to a new class of 2-(4-arylquinazolin-2-yl)anilines that were often difficult to prepare using previous methods. In particular, the newly produced amino group is amenable to further synthetic elaborations, thereby broadening the diversity of the products. The structure of the newly synthesized 2-(4- arylquinazolin-2-yl)anilines was unambiguously confirmed by X-ray crystallography. Moreover, a possible mechanism for the formation of 2-(4-arylquinazolin-2- yl)anilines is discussed.

http://dx.doi.org/10.1002/adsc.201800615