温州大学化学与材料工程学院

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陈久喜老师和邵银林老师指导研究生张业彤在 J. Org. Chem 上发表研究论文

发布时间:2019-02-27    来源:化学与材料工程学院    作者:    点击次    [点击关闭]

Selenium-Catalyzed Oxidative CH Amination of (E)3-(Arylamino)-2-styrylquinazolin-4(3H)ones: A Metal-Free Synthesis of 1,2-Diarylpyrazolo[5,1b]quinazolin-9(1H)ones

Yetong Zhang, Yinlin Shao,* Julin Gong, Jianghe Zhu, Tianxing Cheng, and Jiuxi Chen*

Abstract:A novel metal-free catalysis protocol for the synthesis of 1,2-diarylpyrazolo[5,1-b]quinazolin-9(1H)-ones via intramolecular oxidative C−H amination of (E)-3- (arylamino)-2-styrylquinazolin-4(3H)-ones has been developed in moderate to good yield. The method shows good functional group tolerance. The presented approach offers a new synthetic pathway toward the core structures of 2,3-fused quinazolinones. Moreover, the present synthetic route can be readily scaled up to gram quantity without difficulty. A possible mechanism involves a seleniranium ion followed by threemembered ring opening to form the C−N bond.

原文链接: https://doi.org/10.1021/acs.joc.8b03179