论文标题：Synthesis of 2-Subsitituted Quinazolines by CsOH-Mediated Direct Aerobic Oxidative Cyclocondensation of 2-Aminoarylmethanols with Nitriles in Air

作者：Song Yao, Kaijing Zhou, Jiabing Wang, Hongen Cao, Lei Yu, Jianzhang Wu,* Peihong Qiu* and Qing Xu*

摘要：By using air as a superior oxidant, a highly atom-efficient synthesis of 2-subsitituted quinazolines is developed by a CsOH-mediated direct aerobic oxidative reaction of the readily available and stable 2-aminoarylmethanols and nitriles. Effectively working as the promoter in the alcohol oxidation, nitrile hydration, and cyclocondesation steps, CsOH is the best base for the reaction. The similar method can also be extended to the synthesis of substituted quinolines starting from methyl ketones instead of nitriles.

论文发表：Green Chem. 2017, 19 (13), 2945-2951.

原文链接：http://dx.doi.org/10.1039/C7GC00977A

具体工作介绍见X-MOL知识平台报道：http://www.x-mol.com/news/9424